Ketamine vs Etomidate for RSI in the Critically Ill: What This NEJM Trial Really Tells Us
Choosing an induction agent starts with the patient’s physiology: perfusion, ventricular reserve, oxygenation, and the consequences of apnea. A reassuring drug reputation cannot replace preparation for deterioration. Study in a Nutshell The RSI trial (online December 2025; print April 2026) randomized 2,365 critically ill adults in 14 US EDs/ICUs to ketamine or etomidate. ED trauma […]